Which of the following statements regarding Familial Advanced Sleep Phase Syndrome (FASPS) is/are true? Select one:

1. A point mutation in Casein Kinase 1ξ renders the enzyme incapable of phosphorylating the protein hPER2, ultimately delaying physiological rhythms by 4-5 hours.
2. Casein Kinase 1ξ is unable to phosphorylate a mutant form of the protein hPER2, preventing the latter's timed degradation and enhancing the auto-repression of hPer2 (the gene coding for hPER2).
3. FASPS typically affects both sleep duration and time of sleep onset.
4. a & c
5. b & c

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