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The membrane of a human cell has a surface area of 145 μm and a hydraulic coefficient Lp of 1.41 x 10 cm atm-1 s-1, and the intracellular domain has an osmolarity of 300 mOsm/L and the extracellular fluid of 270 mOsm/L. Consider also that there is no difference in hydrostatic pressure across the pores of the cell membrane. Assume that all the solute intracellularly has a reflection coefficient σ = 1. Based on this information: a) Calculate the volume flow rate of the water. In which direction does the water flow? b) Assuming that the volume intracellularly is 1 x 10-10 cm3, how much water volume is required to dilute the intracellular domain so it has the same osmolarity as the extracellular domain? c) How long does it take for the water to move? Calculate the value. Assume T = 310 K and R = 0.082 L atm mol-1 K-1.
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Question Text | The membrane of a human cell has a surface area of 145 μm and a hydraulic coefficient Lp of 1.41 x 10 cm atm-1 s-1, and the intracellular domain has an osmolarity of 300 mOsm/L and the extracellular fluid of 270 mOsm/L. Consider also that there is no difference in hydrostatic pressure across the pores of the cell membrane. Assume that all the solute intracellularly has a reflection coefficient σ = 1. Based on this information:
a) Calculate the volume flow rate of the water. In which direction does the water flow?
b) Assuming that the volume intracellularly is 1 x 10-10 cm3, how much water volume is required to dilute
the intracellular domain so it has the same osmolarity as the extracellular domain?
c) How long does it take for the water to move? Calculate the value.
Assume T = 310 K and R = 0.082 L atm mol-1 K-1.
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Topic | All topics |
Subject | Biology |
Class | Class 11 |