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Solve the following questions with regards to elimination: d) Drug X binds to plasma protein (fu=0.7) and has a total clearance of 500 ml/min with 75% of the dose excreted unchanged. What is the renal clearance? What is the non-renal clearance? e) A patient receiving a constant infusion of a drug has a steady-state Cp of 6 μg/ml. In 24 hours, the urine output is 1200 ml with a urine drug concentration of 1.44 μg/ml. The drug does not bind to plasma proteins. What is the renal clearance? What processes are involved in the renal clearance? f) Drug Z, which is 25% bound to plasma proteins, has a renal clearance of 7.68 L/hr. If the plasma levels of Drug Z are 50 μg/ml, how many milligrams are eliminated in 2 hours?
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Question Text | Solve the following questions with regards to elimination:
d) Drug X binds to plasma protein (fu=0.7) and has a total clearance of 500 ml/min with 75% of the dose excreted unchanged. What is the renal clearance? What is the non-renal clearance?
e) A patient receiving a constant infusion of a drug has a steady-state Cp of 6 μg/ml. In 24 hours, the urine output is 1200 ml with a urine drug concentration of 1.44 μg/ml. The drug does not bind to plasma proteins. What is the renal clearance? What processes are involved in the renal clearance?
f) Drug Z, which is 25% bound to plasma proteins, has a renal clearance of 7.68 L/hr. If the plasma levels of Drug Z are 50 μg/ml, how many milligrams are eliminated in 2 hours?
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Topic | All topics |
Subject | Biology |
Class | Class 11 |