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In this problem, we examine the hydrostatic pressure in a fluid at rest.(a) Consider a small fluid element at rest. Write down the balance of forces on the fluid element due to the fluid pressure and the gravitational pull of the Earth. Show that this leads to the differential equationwhere is the acceleration due to gravity.(b) Solve the differential equation derived in (a) assuming a uniform fluid density. Show that the pressure in the fluid is given by where the z-axis is in the direction opposite to g.(c) Estimate the atmospheric pressure. (Hint: Look up the density of air and make a reasonable guess for the height of the atmosphere.)(d) If you raise your arm above your head as the doctor is measuring your blood pressure, how much will the measurement change compared with when you keep your arm level with the heart. Try it next time you are at the doctor's officel

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Based on what you know about the genetic code, would a mutation in a gene always lead to an altered protein? Write out the primary sequence of the RNA transcript starting at +1 and continuing until the end of the sequence provided in Box I on the last page of this handout. (Write out the '...'s as well.) *Hint: Have one group member read out the bases from the correct strand in the correct 5'→ 3' direction, and have another write them down. Find and underline the sequence corresponding to the intron in the pre-mRNA sequence you wrote out in Box I. *Hint: Look for the four nucleotide stretch AGGU, which is invariant in the 5' consensus sequence, and then look at flanking nucleotides to determine if they match the rest of the 5' consensus sequence. Subsequently, look for the four nucleotide stretch CAGG, which is invariant in the 3' consensus sequence. Write the sequence of the mature mRNA after intron 1 has been spliced out in Box II (on the last page of this handout). Make sure you make the correct junction between exon 1 and exon 2 by paying attention to the precise 5' and 3' splice sites. Identify and underline the start codon in the mRNA sequence that you wrote out in Box II. *Hint: In the gene Q mRNA the start codon is located closest to the 5' end of the mature mRNA. Once the reading frame start is located, the rest of the codons can be identified by organizing the nucleotides into contiguous sets of three at a time. The end of the reading frame is defined by the presence of one of the three possible stop codons in the same frame. For the mature mRNA sequence above (Box II), identify the reading frame and all of the codons, including the stop codon, in the mature mRNA. Underline the start codon, circle the three bases that code for each following codon, and draw a square around the stop codon. Based on the genetic code and mature gene mRNA sequence, write out the primary sequence (the sequence of amino acids of protein Q) in Box III (last page of this handout). What consequence would this have on the protein? Would it affect the sequence of the protein, the length, or both? *Hint: Consider where the start codon is in the original gene sequence and consider the frame after introduction of the mutation.
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In this problem, we examine the hydrostatic pressure in a fluid at rest.(a) Consider a small fluid element at rest. Write down the balance of forces on the fluid element due to the fluid pressure and the gravitational pull of the Earth. Show that this leads to the differential equationwhere is the acceleration due to gravity.(b) Solve the differential equation derived in (a) assuming a uniform fluid density. Show that the pressure in the fluid is given by where the z-axis is in the direction opposite to g.(c) Estimate the atmospheric pressure. (Hint: Look up the density of air and make a reasonable guess for the height of the atmosphere.)(d) If you raise your arm above your head as the doctor is measuring your blood pressure, how much will the measurement change compared with when you keep your arm level with the heart. Try it next time you are at the doctor's officel
TopicAll topics
SubjectBiology
ClassClass 11