Homeotherms (e.g., birds, mammals...) maintain homeostatic (nearly constant) body temperatures. You might assume then that healthy human cells maintain the 37°C temperature that we detect under our tongue, under our arms, in our ears, or elsewhere (maybe somewhat uncomfortably). Would it come as a surprise to find a study suggesting that mitochondria operate at much higher temperatures, possibly 50°C or more (here or here)? If true, how might that affect our thinking about molecular events in the mitochondrion and in the cytoplasm?

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