Explain why EACH answer choice is correct Part of the introduction explains: "Genetic factors play an important role in late-onset AIzheimer's disease(LOAD)as demonstrated by twin data indicating heritability in the range of 58%-79%[1].The epsilon 4 allele of APOE is the strongest known genetic risk factor for AD with a two to three-fold increased risk for AD in people with one epsilon 4 allele rising to about 12-fold in those with two alleles. APOE is a structural gene that codes for the apolipoprotein 4 which carries cholesterols and other types of fat in the bloodstream.Although Epsilon 4 alleles increase the risk tremendously,it is not 100% sure that E4 E4 individuals will develop Alzheimer's.Also,there are individuals that do not have that genotype and still develop Alzheimer's disease Which of the following statements could explain this inheritance pattern? APOE might be an epistatic gene Different regulatory genes might affect the expression of E4 alleles Alzheimer's is definitely Mendelian APOE might be a hypostatic gene V Other structural genes might be involved in the development of Alzheimer's Epigenetics might be involved in the development of Alzheimer's

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