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Ebola is a deadly disease caused by a virus. Symptoms of this infectious disease include fever, tiredness, muscle
- aches, and a sore throat. This disease may limit the ability of organs like the kidney and liver to function properly an
- may cause bleeding of the gums and internal bleeding. In 2014 the Ebola disease affected multiple countries in Wes
- Africa.
- Is the spread of the Ebola disease epidemic or pandemic?
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Exercise 1. Online Mendelian Inheritance in Man (OMIM)
1. What are the main clinical features of Fragile X syndrome? (1 mark)
2. Why is the syndrome called Fragile X syndrome? (1 mark)
3. What is the function of the protein encoded by FMR1? In what tissues is it expressed? (2 marks)
Exercise 2. Using Genome Data Viewer to study gene structure
4. Is FMR1 transcribed towards the telomere or centromere of the X chromosome? How do you know? (1 mark)
5. What is the size of the FMR1 gene for entry NM_002024.6? (1 mark)
6. How many exons and introns does NM_002024.6 have? How many exons and introns does NM_033699.2 have? (1 mark)
7. Explain why there is a difference between the number of exons in NM_002024.6 compared to NM_033699.2? (1 mark)
Exercise 3. Using Sequence Viewer to study gene locations
8. At what nucleotide position does transcription (not translation) of the FMR1 gene commence? (1 mark)
9. What are the nucleotide positions of the beginning and end of the second exon of the FMR1 gene? (1 mark)
Exercise 4. Searching for human variation using genome databases
10. What is the allelic sequence of variant rs1324566617 and the class of variant? (1 mark)
11. What is the location of this variant in relation to features of the gene such as UTRs and exons? (1 mark)
12. What is the number of CGG repeats downstream of the insertion site? (1 mark)
13. Explain how CGG repeats lead to Fragile X syndrome, including the link between gene sequence, structure, expression, protein, and the hallmark clinical feature of Fragile X syndrome. (2 marks)Question 4
12. The recommended amount of barium sulfate given to a child 1 to 3 years of age for an upper gastrointestinal series is A. 0.8 to 10 ounces B. 0.4 to 6 ounces C. 0.6 to 8 ounces D. 0.2 to 0.4 ounces
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| Question Text | Ebola is a deadly disease caused by a virus. Symptoms of this infectious disease include fever, tiredness, muscle |
| Topic | All topics |
| Subject | Biology |
| Class | Class 11 |
