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Assume that RabA and RabB are the two Rab proteins. Between Compartment A and Compartment B, RabA travels on vesicles, and RabB travels between Compartment B and Compartment C on vesicles. Give a detailed description of the Rab cascade's sequence of events that would enable high-fidelity vesicular transport using Compartment B as the donor compartment. Indicate in detail the order in which the GEF and GAP would be activated, whether RabA and RabB are in the GDP-bound or GTP-bound form at each step, and which Rab would be in charge of each activation.
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Question Text | Assume that RabA and RabB are the two Rab proteins. Between Compartment A and Compartment B, RabA travels on vesicles, and RabB travels between Compartment B and Compartment C on vesicles. Give a detailed description of the Rab cascade's sequence of events that would enable high-fidelity vesicular transport using Compartment B as the donor compartment. Indicate in detail the order in which the GEF and GAP would be activated, whether RabA and RabB are in the GDP-bound or GTP-bound form at each step, and which Rab would be in charge of each activation.
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Topic | All topics |
Subject | Biology |
Class | Class 11 |