2. Cell growth is commonly regulated by signaling receptors. whose levels at the cell surface are tightly controlled. Receptor downregulation occurs by clathrin-mediated endocytosis and degradation in the lysosome. What would be the consequences of a mutation in the AP2 adaptor, which is necessary for clathrin- mediated endocytosis? A: Receptor is taken up but cannot be degraded B: Receptor is endocytosed and degraded by alternative pathways C: Receptor is transported to the TGN D: Receptor is blocked in the ER during its intracellular transport E: Receptor remains at the cell surface leading to enhanced cell growth

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