1. What practice is sometimes used to ensure that patients take all of their tuberculosis medication? Why might this practice be difficult in rural or underdeveloped areas?

1. 2. How does non-compliance with antibiotic treatment regimens lead to the generation of drug-resistant bacteria?
2. 3. The mutation for drug resistance in Mycobacterium tuberculosis, the bacteria that causes the disease tuberculosis, occurs within the chromosome, not in the plasmid. How do you think this would affect the likelihood of an individual bacterium becoming drug-resistant?
3. 4. How will treatment for the second tuberculosis infection likely differ from the first round?
4. 5. What are some qualities of M. tuberculosis that make occurrences of antibacterial resistance so prevalent?

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