Assertion: A tumor of adrenal cortex may cause Addison’s disease.
Reason: This happens due to over secretion of cortisol by the tumor.

A destruction of adrenal cortex by diseases like tuberculosis produces Addison’s disease, due to the deficiency of glucocorticoids and mineralocorticoids which are secreted by the adrenal cortex regions zona fasciculata and zona glomerulosa respectively. Symptoms of Addison’s disease include a bronze-like pigmentation of skin, low blood sugar, low plasma Na${}^{+}$ , high plasma K${}^{+}$ , increased urinary Na${}^{+}$ , nausea, vomiting and diarrhoea.
Cortisol is a glucocorticoid which regulates the metabolisms of carbohydrates, fats and proteins. A tumor of the adrenal cortex may secrete too much cortisol to produce Cushing’s syndrome. High blood sugar, appearance of sugar in the urine, obesity, wasting of limb muscles, rise in plasma Na${}^{+}$ , fall in plasma K${}^{+}$ , rise in blood volume and high blood pressure are observed in the patient suffering from Cushing’s syndrome.